Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.42 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 4/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 4/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1046083 | 0.98 | MAPKAPK5 (0.44) | HRH3MAPKAPK5JAK2CDK4CCND1 | |
| SCHEMBL1046040 | 0.97 | HRH3 (0.44) | HRH3MAPKAPK5JAK2CDK4CCND1 | |
| SCHEMBL1046529 | 0.96 | MAPKAPK5 (0.45) | HRH3MAPKAPK5JAK2CDK4CCND1 | |
| SCHEMBL1048653 | 0.84 | MAPKAPK5 (0.58) | MAPKAPK5JAK2JAK3JAK1TBK1 | |
| SCHEMBL10134407 | 0.83 | MAPKAPK5 (0.56) | HRH3MAPKAPK5JAK2CDK4CCND1 | |
| SCHEMBL10134415 | 0.82 | MAPKAPK5 (0.56) | HRH3MAPKAPK5JAK2CDK4CCND1 | |
| SCHEMBL1045287 | 0.82 | MAPKAPK5 (0.45) | MAPKAPK5JAK2CDK6 | |
| SCHEMBL1046936 | 0.81 | MAPKAPK5 (0.44) | MAPKAPK5JAK2JAK3SYK | |
| SCHEMBL10134447 | 0.80 | MAPKAPK5 (0.58) | HRH3MAPKAPK5JAK2JAK3BTK | |
| SCHEMBL1044218 | 0.80 | MAPKAPK5 (0.44) | MAPKAPK5JAK2JAK3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086540-B8 | TRIAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2011-03-02 | — | — | EP | claimed |