Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 20/20 | 0.89 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.84 |
| ▸ | HRH1 | P35367 | 2/20 | 0.84 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14006758 | 0.98 | HRH3 (0.93) | HRH3KCNH2HRH1CYP2D6 | |
| SCHEMBL14006747 | 0.92 | HRH3 (0.81) | HRH3KCNH2HRH1CYP2D6 | |
| SCHEMBL14006757 | 0.92 | HRH3 (0.80) | HRH3KCNH2HRH1CYP2D6 | |
| SCHEMBL14006619 | 0.92 | HRH3 (0.98) | HRH3KCNH2HRH1CYP2D6 | |
| SCHEMBL14006627 | 0.92 | HRH3 (0.98) | HRH3KCNH2HRH1CYP2D6 | |
| SCHEMBL14006616 | 0.92 | HRH3 (0.98) | HRH3KCNH2HRH1CYP2D6 | |
| SCHEMBL14006603 | 0.92 | HRH3 (0.98) | HRH3KCNH2HRH1CYP2D6 | |
| SCHEMBL14006691 | 0.91 | HRH3 (0.82) | HRH3KCNH2HRH1CYP2D6 | |
| SCHEMBL14640616 | 0.91 | HRH3 (0.81) | HRH3KCNH2HRH1CYP2D6 | |
| SCHEMBL14006761 | 0.90 | HRH3 (0.94) | HRH3KCNH2HRH1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080275027-A1 | Piperazinone Derivatives Useful as Histamine H3 Receptor Antagonists and/or Inverse Agonists | GLAXO GROUP LIMITED (GB) | 2008-11-06 | — | — | US | disclosed |
| US-20080275027-A1 | Piperazinone Derivatives Useful as Histamine H3 Receptor Antagonists and/or Inverse Agonists | GLAXO GROUP LIMITED (GB) | 2008-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275027-A1 | Piperazinone Derivatives Useful as Histamine H3 Receptor Antagonists and/or Inverse Agonists | HRH3, HRH1, HRH4 | HRH3 1/4885KCNH2 497/4885HRH1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.