Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 8/20 | 0.64 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | YES1 | P07947 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 3/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | ESRRB | O95718 | 1/20 | 0.39 |
| ▸ | ESRRA | P11474 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3532558 | 0.79 | SRC (0.67) | SRCPIK3CGPABPC1PDPK1 | |
| SCHEMBL41115 | 0.79 | LCK (0.53) | SRCEPHB4ABL1ESR1ESR2 | |
| SCHEMBL4265952 | 0.79 | SRC (1.00) | SRCYES1ABL1PDGFRB | |
| SCHEMBL31061003 | 0.76 | SRC (1.00) | SRCPIK3CGPABPC1ESR1ESR2 | |
| SCHEMBL3737100 | 0.76 | SRC (1.00) | SRCPIK3CGPABPC1ESR1ESR2 | |
| SCHEMBL14008915 | 0.73 | SRC (0.74) | SRCPIK3CGPABPC1YES1EPHB4 | |
| SCHEMBL13019078 | 0.72 | SRC (0.67) | SRCPIK3CGPABPC1ESR1ESR2 | |
| SCHEMBL7778555 | 0.70 | HSD17B10 (0.54) | ABL1ESR1ESR2CA12CA1 | |
| SCHEMBL13838412 | 0.69 | PIK3CD (0.50) | SRCABL1ESR1ESR2CA12 | |
| SCHEMBL6366137 | 0.69 | PIK3CG (1.00) | SRCPIK3CGPABPC1PDPK1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456176-B2 | Benzotriazine inhibitors of kinases | TARGEGEN, INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-7456176-B2 | Benzotriazine inhibitors of kinases | TARGEGEN, INC. (US) | 2008-11-25 | — | — | US | disclosed |