Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLNR | O43193 | 19/20 | 0.84 |
| ▸ | GHSR | Q92847 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12220294 | 0.93 | MLNR (0.87) | MLNRGHSR | |
| SCHEMBL73759 | 0.92 | MLNR (0.85) | MLNRGHSR | |
| SCHEMBL73793 | 0.92 | MLNR (0.88) | MLNRGHSR | |
| SCHEMBL73745 | 0.91 | MLNR (0.82) | MLNR | |
| SCHEMBL73797 | 0.91 | MLNR (0.85) | MLNR | |
| SCHEMBL75370 | 0.91 | MLNR (0.85) | MLNR | |
| SCHEMBL13392520 | 0.91 | MLNR (0.76) | MLNR | |
| SCHEMBL73308 | 0.90 | MLNR (0.85) | MLNRGHSR | |
| SCHEMBL74135 | 0.89 | MLNR (1.00) | MLNRGHSR | |
| SCHEMBL73783 | 0.89 | MLNR (0.84) | MLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7452862-B2 | Conformationally-controlled biologically active macrocyclic small molecules as motilin antagonists or ghrelin agonists | TRANZYME PHARMA, INC. (CA) | 2008-11-18 | — | — | US | disclosed |
| US-7452862-B2 | Conformationally-controlled biologically active macrocyclic small molecules as motilin antagonists or ghrelin agonists | TRANZYME PHARMA, INC. (CA) | 2008-11-18 | — | — | US | disclosed |