Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.52 |
| ▸ | MAP3K12 | Q12852 | 9/20 | 0.38 |
| ▸ | TNF | P01375 | 2/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.34 |
| ▸ | DLK1 | P80370 | 2/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3514771 | 0.93 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3CBPIK3CGMAP3K12 | |
| SCHEMBL12989736 | 0.92 | PIK3CA (0.54) | PIK3CAPIK3CDPIK3CBPIK3CGMAP3K12 | |
| SCHEMBL3513244 | 0.91 | PIK3CA (0.53) | PIK3CAPIK3CDPIK3CBPIK3CGMAP3K12 | |
| SCHEMBL3512765 | 0.90 | PIK3CA (0.55) | PIK3CAPIK3CDPIK3CBPIK3CGMAP3K12 | |
| SCHEMBL3512456 | 0.89 | PIK3CA (0.51) | PIK3CAPIK3CDPIK3CBPIK3CGTNF | |
| SCHEMBL12990063 | 0.89 | PIK3CA (0.53) | PIK3CAPIK3CDPIK3CBPIK3CGMAP3K12 | |
| SCHEMBL3512134 | 0.84 | PIK3CA (0.62) | PIK3CAPIK3CDPIK3CBPIK3CGMAP3K12 | |
| SCHEMBL3516013 | 0.82 | PIK3CA (0.46) | PIK3CAPIK3CDPIK3CBPIK3CGTNF | |
| SCHEMBL3514705 | 0.80 | TNF (0.45) | PIK3CAPIK3CDPIK3CBPIK3CGTNF | |
| SCHEMBL14014043 | 0.77 | PIK3CA (0.45) | PIK3CAPIK3CDPIK3CBPIK3CGTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008138834-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES AS PI3K LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-11-20 | — | — | WO | disclosed |