Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | RPA1 | P27694 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | GAA | P10253 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | GLA | P06280 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | STAT1 | P42224 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014249 | 0.87 | KDM4E (0.79) | MEN1KMT2AATMRPA1ALDH1A1 | |
| SCHEMBL14014181 | 0.84 | KDM4E (0.61) | MEN1KMT2AATMRPA1ALDH1A1 | |
| SCHEMBL14014221 | 0.81 | KDM4E (0.70) | MEN1KMT2AATMRPA1ALDH1A1 | |
| SCHEMBL22491836 | 0.81 | MCL1 (0.52) | MEN1KMT2AATMRPA1ALDH1A1 | |
| SCHEMBL14014192 | 0.78 | KDM4E (0.64) | MEN1KMT2AATMRPA1ALDH1A1 | |
| SCHEMBL14014213 | 0.78 | KDM4E (0.64) | MEN1KMT2AATMALDH1A1KDM4E | |
| SCHEMBL14014350 | 0.77 | KDM4E (0.63) | MEN1KMT2ARPA1ALDH1A1KDM4E | |
| SCHEMBL12465733 | 0.77 | MCL1 (0.51) | MEN1KMT2AATMRPA1ALDH1A1 | |
| SCHEMBL14014274 | 0.77 | KDM4E (0.70) | MEN1KMT2ARPA1ALDH1A1KDM4E | |
| SCHEMBL14014260 | 0.77 | KDM4E (0.62) | MEN1KMT2AATMRPA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |