Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.81 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | HPGD | P15428 | 8/20 | 0.56 |
| ▸ | HTT | P42858 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014216 | 1.00 | KDM4E (0.81) | KDM4EALDH1A1MCL1MAPTMAPK1 | |
| SCHEMBL14014231 | 0.99 | KDM4E (0.79) | KDM4EALDH1A1MCL1MAPTMAPK1 | |
| SCHEMBL14014230 | 0.99 | KDM4E (0.78) | KDM4EALDH1A1MCL1MAPTMAPK1 | |
| SCHEMBL14014219 | 0.93 | KDM4E (0.70) | KDM4EALDH1A1MCL1MAPTMAPK1 | |
| SCHEMBL6211856 | 0.93 | KDM4E (0.70) | KDM4EALDH1A1MCL1MAPTMAPK1 | |
| SCHEMBL14014233 | 0.93 | KDM4E (0.70) | KDM4EALDH1A1MCL1MAPTMAPK1 | |
| SCHEMBL14014221 | 0.93 | KDM4E (0.70) | KDM4EALDH1A1MCL1MAPTMAPK1 | |
| SCHEMBL14014217 | 0.90 | KDM4E (0.65) | KDM4EALDH1A1MCL1MAPTMAPK1 | |
| SCHEMBL14014218 | 0.90 | KDM4E (0.65) | KDM4EALDH1A1MCL1MAPTMAPK1 | |
| SCHEMBL14014281 | 0.90 | KDM4E (0.65) | KDM4EALDH1A1MCL1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |