Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5100310 | 1.00 | MAPK14 (0.49) | MAPK14MAPK11LPAR2 | |
| SCHEMBL14015122 | 1.00 | MAPK14 (0.49) | MAPK14MAPK11LPAR2 | |
| SCHEMBL5093585 | 0.93 | MAPK14 (0.49) | MAPK14MAPK11LPAR2 | |
| SCHEMBL4015530 | 0.89 | MAPK14 (0.51) | MAPK14MAPK11LPAR2 | |
| SCHEMBL4016175 | 0.89 | MAPK14 (0.49) | MAPK14MAPK11 | |
| SCHEMBL5093706 | 0.88 | MAPK14 (0.50) | MAPK14MAPK11LPAR2 | |
| SCHEMBL4013145 | 0.88 | MAPK14 (0.46) | MAPK14MAPK11LPAR2 | |
| SCHEMBL13764813 | 0.88 | MAPK14 (0.46) | MAPK14MAPK11LPAR2 | |
| SCHEMBL5093937 | 0.85 | MAPK14 (0.48) | MAPK14MAPK11LPAR2 | |
| SCHEMBL14015108 | 0.85 | MAPK14 (0.48) | MAPK14MAPK11LPAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7452880-B2 | Substituted pyrazolo [3,4-d] pyrimidines and methods of using the same | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-18 | — | — | US | disclosed |
| US-7452880-B2 | Substituted pyrazolo [3,4-d] pyrimidines and methods of using the same | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-18 | — | — | US | disclosed |