Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 5/20 | 0.44 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14015683 | 0.80 | RET (0.44) | RETMERTKSMN1; SMN2PDE1APDE1B | |
| SCHEMBL13858455 | 0.77 | MAPT (0.51) | RECQLKDM4EALDH1A1GLAHPGD | |
| SCHEMBL14015668 | 0.76 | ESR1 (0.44) | MERTKRECQLKDM4EALDH1A1PDE1A | |
| SCHEMBL13858360 | 0.75 | PDE1A (0.49) | RETMERTKKDM4EALDH1A1GLA | |
| SCHEMBL16200211 | 0.73 | MEN1 (0.48) | RECQLKDM4EALDH1A1GLAHPGD | |
| SCHEMBL13715965 | 0.73 | HTR2A (0.44) | RETMERTKRECQLPDE1APDE1B | |
| SCHEMBL13860832 | 0.72 | NPC1 (0.51) | KDM4EALDH1A1GLAHPGDLMNA | |
| SCHEMBL17054305 | 0.70 | PDE1A (0.51) | RETMERTKRECQLKDM4EALDH1A1 | |
| SCHEMBL12377267 | 0.70 | NPC1 (0.45) | RETALDH1A1SMN1; SMN2PDE1APDE1B | |
| SCHEMBL23402056 | 0.69 | KMT2A (0.45) | RETMERTKRECQLLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449576-B1 | potent antagonists of the CCR1 receptor; inflammation; (5-Chloro-2-piperazin-1-yl-phenyl)-phenyl-methanone | CHEMOCENTRYX, INC. (US) | 2008-11-11 | — | — | US | disclosed |