SCHEMBL14017201

SCHEMBL14017201

Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCNCC3)CC2)cc(Cl)c1N

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CALCRL Q16602 19/20 0.65
CYP3A4 P08684 17/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14017195 0.96 CALCRL (0.66) CALCRLCYP3A4
SCHEMBL14017285 0.94 CALCRL (0.73) CALCRLCYP3A4
SCHEMBL13331927 0.94 CALCRL (0.57) CALCRLCYP3A4
SCHEMBL14017015 0.94 CALCRL (0.68) CALCRLCYP3A4
SCHEMBL14017226 0.94 CALCRL (0.74) CALCRLCYP3A4
SCHEMBL14016998 0.93 CALCRL (0.67) CALCRLCYP3A4
SCHEMBL14017223 0.93 CALCRL (0.60) CALCRLCYP3A4
SCHEMBL14017087 0.93 CALCRL (0.64) CALCRLCYP3A4
SCHEMBL14017000 0.93 CALCRL (0.65) CALCRLCYP3A4
SCHEMBL14016777 0.91 CALCRL (0.69) CALCRLCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7439237-B2 Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-10-21 US disclosed