Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.73 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.64 |
| ▸ | GSK3A | P49840 | 3/20 | 0.64 |
| ▸ | GSK3B | P49841 | 3/20 | 0.64 |
| ▸ | EGFR | P00533 | 2/20 | 0.64 |
| ▸ | INSR | P06213 | 2/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.64 |
| ▸ | FLT1 | P17948 | 1/20 | 0.64 |
| ▸ | FLT4 | P35916 | 1/20 | 0.64 |
| ▸ | BRAF | P15056 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4996034 | 0.85 | KDR (0.74) | KDRFGFR2GSK3AGSK3BEGFR | |
| SCHEMBL4672282 | 0.85 | KDR (1.00) | KDRFGFR2GSK3AGSK3BEGFR | |
| SCHEMBL1122025 | 0.83 | KDR (0.70) | KDRFGFR2GSK3AGSK3BEGFR | |
| SCHEMBL1123240 | 0.81 | KDR (0.67) | KDRFGFR2GSK3AGSK3BEGFR | |
| SCHEMBL4987209 | 0.81 | KDR (0.79) | KDRFGFR2GSK3AGSK3BEGFR | |
| SCHEMBL14018401 | 0.80 | ABL1 (0.52) | KDRFGFR2GSK3AGSK3BEGFR | |
| SCHEMBL4996941 | 0.80 | KDR (0.81) | KDRFGFR2GSK3AGSK3BEGFR | |
| SCHEMBL14017844 | 0.79 | KDR (0.64) | KDRFGFR2GSK3AGSK3BEGFR | |
| SCHEMBL14017617 | 0.79 | KDR (0.65) | KDRFGFR2GSK3AGSK3BEGFR | |
| SCHEMBL6957081 | 0.79 | KDR (0.63) | KDRFGFR2GSK3AGSK3BEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1330452-B1 | PYRAZINE DERIVATIVES AS MODULATORS OF TYROSINE KINASES | ORTHO MCNEIL PHARM INC (US) | 2008-11-26 | — | — | EP | disclosed |