Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.55 |
| ▸ | RAF1 | P04049 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | KIT | P10721 | 1/20 | 0.55 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.55 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 5/20 | 0.47 |
| ▸ | NR2E1 | Q9Y466 | 3/20 | 0.40 |
| ▸ | RORA | P35398 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4846748 | 0.90 | KDR (0.58) | KDRRAF1LCKRETCYP3A4 | |
| SCHEMBL4846740 | 0.90 | KDR (0.58) | KDRRAF1LCKRETCYP3A4 | |
| SCHEMBL4849817 | 0.90 | KDR (0.53) | KDRRAF1LCKRETCYP3A4 | |
| SCHEMBL4849820 | 0.90 | KDR (0.53) | KDRRAF1LCKRETCYP3A4 | |
| SCHEMBL4843794 | 0.89 | KDR (0.54) | KDRRAF1LCKRETCYP3A4 | |
| SCHEMBL4852047 | 0.89 | KDR (0.55) | KDRRAF1LCKRETCYP3A4 | |
| SCHEMBL4852051 | 0.89 | KDR (0.55) | KDRRAF1LCKRETCYP3A4 | |
| SCHEMBL4843791 | 0.89 | KDR (0.54) | KDRRAF1LCKRETCYP3A4 | |
| SCHEMBL14019057 | 0.87 | KDR (0.59) | KDRRAF1LCKRETCYP3A4 | |
| SCHEMBL4845175 | 0.87 | KDR (0.59) | KDRRAF1LCKRETCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7439256-B2 | (Arylamidoaryl) cyanoguanidine compounds | OSI PHARMACEUTICALS, INC. | 2008-10-21 | — | — | US | disclosed |
| US-7439256-B2 | (Arylamidoaryl) cyanoguanidine compounds | OSI PHARMACEUTICALS, INC. | 2008-10-21 | — | — | US | disclosed |