Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14019177 | 0.92 | SMN1; SMN2 (0.51) | SMN1; SMN2PTGER1NPC1RAB9APOLB | |
| SCHEMBL4759799 | 0.88 | SMN1; SMN2 (0.56) | SMN1; SMN2PTGER1NPC1RAB9APOLB | |
| SCHEMBL14019190 | 0.87 | SMN1; SMN2 (0.56) | SMN1; SMN2PTGER1NPC1RAB9APOLB | |
| SCHEMBL4759503 | 0.84 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9APOLBMAPT | |
| SCHEMBL14108669 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2PTGER1NPC1RAB9APOLB | |
| SCHEMBL8111687 | 0.83 | SMN1; SMN2 (0.54) | SMN1; SMN2PTGER1NPC1RAB9APOLB | |
| SCHEMBL14019193 | 0.80 | SMN1; SMN2 (0.41) | SMN1; SMN2PTGER1KDM4EMAP3K5 | |
| SCHEMBL27415197 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1RAB9APOLBMAPT | |
| SCHEMBL1267682 | 0.79 | SMN1; SMN2 (0.57) | SMN1; SMN2PTGER1NPC1RAB9APOLB | |
| SCHEMBL14019185 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432379-B2 | Substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists | ELAN PHARMACEUTICALS, INC. (US) | 2008-10-07 | — | — | US | disclosed |
| US-7417152-B2 | 4-bromo-5-(2-chloro-benzoylamino)-1H-pyrazole-3-carboxylic acid amide derivatives and related compounds as bradykinin B1 receptor antagonists for the treatment of inflammatory diseases | ELAN PHARMACEUTICALS, INC. (US) | 2008-08-26 | — | — | US | disclosed |
| US-7417152-B2 | 4-bromo-5-(2-chloro-benzoylamino)-1H-pyrazole-3-carboxylic acid amide derivatives and related compounds as bradykinin B1 receptor antagonists for the treatment of inflammatory diseases | ELAN PHARMACEUTICALS, INC. (US) | 2008-08-26 | — | — | US | disclosed |