Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 3/20 | 0.41 |
| ▸ | TDO2 | P48775 | 3/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | IL1B | P01584 | 3/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1750429 | 0.83 | POLB (0.46) | LTA4HHTR5A | |
| SCHEMBL19353591 | 0.82 | IDO1 (0.49) | LTA4HIDO1TDO2SCN9AIL1B | |
| SCHEMBL17056178 | 0.78 | IDO1 (0.42) | IDO1TDO2SCN9AIL1B | |
| SCHEMBL21376997 | 0.78 | SCN9A (0.51) | LTA4HSCN9A | |
| SCHEMBL3652732 | 0.77 | KMT2A (0.51) | LTA4H | |
| SCHEMBL1162602 | 0.77 | POLB (0.56) | LTA4H | |
| SCHEMBL10132546 | 0.77 | POLB (0.56) | LTA4HIDO1TDO2HTR6 | |
| SCHEMBL22456442 | 0.77 | POLB (0.56) | LTA4HIDO1TDO2HTR6 | |
| SCHEMBL1162536 | 0.77 | POLB (0.56) | LTA4H | |
| SCHEMBL8854588 | 0.77 | POLB (0.56) | LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1337517-B1 | PYRIMIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 2008-11-26 | — | — | EP | disclosed |