Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.54 |
| ▸ | IKBKB | O14920 | 1/20 | 0.53 |
| ▸ | CHUK | O15111 | 1/20 | 0.53 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.53 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 6/20 | 0.49 |
| ▸ | JAK3 | P52333 | 4/20 | 0.49 |
| ▸ | SYK | P43405 | 2/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3056212 | 0.90 | AIMP2 (0.54) | DRD2IKBKBCHUKAIMP2PIK3CA | |
| SCHEMBL14021310 | 0.89 | SYK (0.53) | IKBKBCHUKIKBKGAIMP2PIK3CA | |
| SCHEMBL14021629 | 0.89 | JAK2 (0.54) | IKBKBCHUKIKBKGAIMP2PIK3CA | |
| SCHEMBL14021298 | 0.88 | SYK (0.52) | DRD2IKBKBCHUKIKBKGAIMP2 | |
| SCHEMBL14021295 | 0.88 | AIMP2 (0.52) | DRD2IKBKBCHUKAIMP2PIK3CA | |
| SCHEMBL13590773 | 0.88 | PIK3CA (0.47) | DRD2IKBKBCHUKIKBKGAIMP2 | |
| SCHEMBL3049760 | 0.87 | SYK (0.51) | IKBKBCHUKIKBKGAIMP2PIK3CA | |
| SCHEMBL14021308 | 0.87 | JAK2 (0.55) | JAK2JAK3SYKJAK1CDK2 | |
| SCHEMBL8311018 | 0.86 | JAK2 (0.61) | IKBKBCHUKIKBKGAIMP2PIK3CA | |
| SCHEMBL14021306 | 0.86 | SYK (0.54) | IKBKBCHUKIKBKGAIMP2PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |