Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.65 |
| ▸ | AURKA | O14965 | 1/20 | 0.65 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.65 |
| ▸ | EGFR | P00533 | 1/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.65 |
| ▸ | INSR | P06213 | 1/20 | 0.65 |
| ▸ | IGF1R | P08069 | 1/20 | 0.65 |
| ▸ | MET | P08581 | 1/20 | 0.65 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.65 |
| ▸ | CDK4 | P11802 | 1/20 | 0.65 |
| ▸ | SRC | P12931 | 1/20 | 0.65 |
| ▸ | BRAF | P15056 | 1/20 | 0.65 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.65 |
| ▸ | CCND1 | P24385 | 1/20 | 0.65 |
| ▸ | CDK2 | P24941 | 1/20 | 0.65 |
| ▸ | AKT1 | P31749 | 1/20 | 0.65 |
| ▸ | FLT4 | P35916 | 1/20 | 0.65 |
| ▸ | KDR | P35968 | 1/20 | 0.65 |
| ▸ | FLT3 | P36888 | 1/20 | 0.65 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30988765 | 0.95 | PLK4 (0.71) | PLK4AURKANUAK1EGFRERBB2 | |
| SCHEMBL14022015 | 0.86 | PLK4 (0.64) | PLK4AURKANUAK1EGFRERBB2 | |
| Hemibastadin 2 SCHEMBL6803113 | 0.85 | PLK4 (0.89) | PLK4AURKANUAK1EGFRERBB2 | |
| SCHEMBL6797800 | 0.85 | PLK4 (0.80) | PLK4AURKANUAK1EGFRERBB2 | |
| SCHEMBL14022701 | 0.82 | PLK4 (0.57) | PLK4AURKANUAK1EGFRERBB2 | |
| Hemibastadin 1 SCHEMBL4751505 | 0.77 | PLK4 (0.82) | PLK4AURKANUAK1EGFRERBB2 | |
| SCHEMBL14022016 | 0.74 | PLK4 (0.51) | PLK4AURKANUAK1EGFRERBB2 | |
| SCHEMBL17445180 | 0.73 | PLK4 (0.65) | PLK4AURKANUAK1EGFRERBB2 | |
| SCHEMBL29500415 | 0.70 | CA1 (0.78) | PLK4AURKANUAK1EGFRERBB2 | |
| Bisaprasin SCHEMBL12522054 | 0.69 | HDAC1 (0.78) | PLK4AURKANUAK1EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008138527-A2 | NOVEL OXIME COMPOUNDS AND THE USE THEREOF AS ANTI-FOULING AGENTS | HEINRICH-HEINE-UNIVERSITÄT DÜSSELDORF (DE) | 2008-11-20 | — | — | WO | disclosed |