Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.72 |
| ▸ | KDR | P35968 | 6/20 | 0.72 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.72 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.72 |
| ▸ | RAF1 | P04049 | 3/20 | 0.72 |
| ▸ | NAMPT | P43490 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.57 |
| ▸ | FAAH | O00519 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15574777 | 0.87 | NAMPT (0.73) | BRAFKDRMAPK14TNNI3KRAF1 | |
| SCHEMBL3177619 | 0.84 | KDR (1.00) | BRAFKDRMAPK14TNNI3KRAF1 | |
| SCHEMBL16907465 | 0.81 | KDR (1.00) | BRAFKDR | |
| SCHEMBL4118836 | 0.81 | MAPT (0.73) | BRAFKDRNAMPTNPC1RAB9A | |
| SCHEMBL4124892 | 0.81 | MEN1 (0.69) | BRAFKDRNPC1RAB9AFLT3 | |
| SCHEMBL938903 | 0.79 | RAF1 (1.00) | BRAFKDRMAPK14TNNI3KRAF1 | |
| SCHEMBL4459698 | 0.78 | BRAF (1.00) | BRAF | |
| SCHEMBL29556410 | 0.78 | MTOR (0.61) | BRAFKDRNPC1RAB9AALDH1A1 | |
| SCHEMBL4110392 | 0.78 | MAPT (0.64) | NPC1RAB9AALDH1A1EPHX2MEN1 | |
| SCHEMBL4112747 | 0.78 | EPHX2 (0.64) | BRAFNPC1RAB9AALDH1A1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269265-A1 | Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas | MILLER SCOTT | 2008-10-30 | — | — | US | disclosed |
| US-20080269265-A1 | Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas | MILLER SCOTT | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269265-A1 | Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas | BRAF, RAF1, MAP2K2 | BRAF 1/4885KDR 834/4885MAPK14 173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.