SCHEMBL14022677

SCHEMBL14022677

FC(F)Oc1cccc([C@H]2CCc3c(cccc3-c3cccc(OC(F)(F)F)c3)N2)c1

nearest known ligand 0.49

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CETP P11597 19/20 0.49
DRD2 P14416 1/20 0.40
DRD1 P21728 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14147470 1.00 CETP (0.49) CETPDRD2DRD1
SCHEMBL14022728 1.00 CETP (0.49) CETPDRD2DRD1
SCHEMBL4038513 0.94 CETP (0.51) CETPDRD2DRD1
SCHEMBL14147773 0.93 CETP (0.49) CETP
SCHEMBL1619216 0.92 CETP (0.56) CETP
SCHEMBL1619210 0.92 CETP (0.56) CETP
SCHEMBL12719940 0.92 CETP (0.56) CETP
SCHEMBL14147673 0.92 CETP (0.44) CETPDRD2DRD1
SCHEMBL4037259 0.92 CETP (0.56) CETP
SCHEMBL14147717 0.89 CETP (0.49) CETP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008141077-A1 PROCESS FOR THE PREPARATION OF TETRAHYDROQUINOLINYL, BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 2008-11-20 WO disclosed