Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.79 |
| ▸ | FLT3 | P36888 | 20/20 | 0.79 |
| ▸ | TYK2 | P29597 | 18/20 | 0.79 |
| ▸ | JAK1 | P23458 | 16/20 | 0.79 |
| ▸ | JAK3 | P52333 | 14/20 | 0.79 |
| ▸ | CDK2 | P24941 | 12/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.55 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14022893 | 0.92 | JAK2 (0.80) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL14022997 | 0.92 | JAK2 (0.92) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL14022818 | 0.92 | JAK2 (0.79) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL14022819 | 0.91 | JAK2 (0.78) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL14022972 | 0.89 | JAK2 (0.68) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL14022844 | 0.88 | JAK2 (1.00) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL14023553 | 0.87 | JAK2 (0.85) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL14022945 | 0.87 | JAK2 (0.60) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL14023557 | 0.87 | JAK2 (0.84) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL14022825 | 0.85 | JAK2 (0.63) | JAK2FLT3TYK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140419-A2 | PYRIDYL SUBSTITUTED PYRIMIDINE DERIVATIVES | S*BIO PTE LTD (SG) | 2008-11-20 | — | — | WO | disclosed |