Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.58 |
| ▸ | FLT3 | P36888 | 20/20 | 0.58 |
| ▸ | CDK2 | P24941 | 18/20 | 0.58 |
| ▸ | TYK2 | P29597 | 16/20 | 0.58 |
| ▸ | JAK1 | P23458 | 14/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 12/20 | 0.58 |
| ▸ | CCNA1 | P78396 | 12/20 | 0.58 |
| ▸ | JAK3 | P52333 | 7/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | STK16 | O75716 | 1/20 | 0.42 |
| ▸ | STK10 | O94804 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PRKCB | P05771 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14022880 | 0.88 | JAK2 (0.51) | JAK2FLT3CDK2TYK2JAK1 | |
| SCHEMBL14022879 | 0.88 | FLT3 (0.49) | JAK2FLT3CDK2TYK2JAK1 | |
| SCHEMBL14022948 | 0.88 | JAK2 (0.59) | JAK2FLT3CDK2TYK2JAK1 | |
| SCHEMBL14022902 | 0.87 | JAK2 (0.76) | JAK2FLT3CDK2TYK2JAK1 | |
| SCHEMBL14023015 | 0.87 | JAK2 (0.75) | JAK2FLT3CDK2TYK2JAK1 | |
| SCHEMBL14022946 | 0.87 | JAK2 (0.52) | JAK2FLT3CDK2TYK2JAK1 | |
| SCHEMBL14023018 | 0.85 | JAK2 (0.78) | JAK2FLT3CDK2TYK2JAK1 | |
| SCHEMBL14022903 | 0.76 | JAK2 (0.69) | JAK2FLT3CDK2TYK2JAK1 | |
| SCHEMBL14022917 | 0.76 | JAK2 (0.75) | JAK2FLT3CDK2TYK2JAK1 | |
| SCHEMBL14022881 | 0.76 | CDK2 (0.60) | JAK2FLT3CDK2TYK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140419-A2 | PYRIDYL SUBSTITUTED PYRIMIDINE DERIVATIVES | S*BIO PTE LTD (SG) | 2008-11-20 | — | — | WO | disclosed |