Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 7/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14023927 | 0.83 | HDAC4 (0.37) | CYP2A6CYP3A4CYP17A1CYP11B2CYP19A1 | |
| SCHEMBL14025090 | 0.83 | CYP17A1 (0.43) | MKNK2CYP3A4CYP17A1KIF11CYP11B2 | |
| SCHEMBL14024017 | 0.79 | MAOB (0.39) | — | |
| SCHEMBL4810655 | 0.79 | MAOB (0.39) | — | |
| SCHEMBL19062805 | 0.79 | CYP2A6 (0.44) | MKNK1MKNK2CYP2A6CYP3A4ALDH1A1 | |
| SCHEMBL14024065 | 0.79 | CYP2A6 (0.44) | MKNK1MKNK2CYP2A6CYP3A4ALDH1A1 | |
| SCHEMBL14024068 | 0.78 | HDAC4 (0.42) | CA12CA1CA2CA9CYP2D6 | |
| SCHEMBL12683774 | 0.78 | MKNK1 (0.44) | MKNK1MKNK2ALDH1A1CYP1A2 | |
| SCHEMBL4752135 | 0.77 | MKNK1 (0.51) | MKNK1MKNK2CYP2A6CYP3A4ALDH1A1 | |
| SCHEMBL14023966 | 0.77 | PIK3CD (0.44) | CYP2A6CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008143729-A2 | MACROLIDE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | RIB-X PHARMACEUTICALS, INC. (US) | 2008-11-27 | — | — | WO | disclosed |