Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.57 |
| ▸ | FLT3 | P36888 | 14/20 | 0.57 |
| ▸ | TYK2 | P29597 | 13/20 | 0.57 |
| ▸ | JAK1 | P23458 | 12/20 | 0.55 |
| ▸ | CDK2 | P24941 | 7/20 | 0.55 |
| ▸ | JAK3 | P52333 | 6/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.43 |
| ▸ | EGFR | P00533 | 6/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14023948 | 0.92 | JAK2 (0.57) | JAK2FLT3TYK2JAK1CDK2 | |
| SCHEMBL14023552 | 0.91 | JAK2 (0.59) | JAK2FLT3TYK2JAK1CDK2 | |
| SCHEMBL14022823 | 0.88 | JAK2 (0.60) | JAK2FLT3TYK2JAK1CDK2 | |
| SCHEMBL14023565 | 0.86 | JAK2 (0.52) | JAK2FLT3TYK2JAK1CDK2 | |
| SCHEMBL14022847 | 0.83 | JAK2 (0.70) | JAK2FLT3TYK2JAK1CDK2 | |
| SCHEMBL14022828 | 0.83 | JAK2 (0.61) | JAK2FLT3TYK2JAK1CDK2 | |
| SCHEMBL14022833 | 0.82 | JAK2 (0.59) | JAK2FLT3TYK2JAK1CDK2 | |
| SCHEMBL14022824 | 0.81 | JAK2 (0.71) | JAK2FLT3TYK2JAK1CDK2 | |
| SCHEMBL14023902 | 0.81 | JAK2 (0.63) | JAK2FLT3TYK2JAK1CDK2 | |
| SCHEMBL14023939 | 0.80 | JAK2 (0.61) | JAK2FLT3TYK2JAK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140419-A2 | PYRIDYL SUBSTITUTED PYRIMIDINE DERIVATIVES | S*BIO PTE LTD (SG) | 2008-11-20 | — | — | WO | disclosed |