Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | MIF | P14174 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19872985 | 1.00 | NPC1 (0.35) | NPC1RAB9ALMNASMN1; SMN2PDE4A | |
| SCHEMBL10085694 | 0.78 | — | — | |
| SCHEMBL21066137 | 0.77 | NPC1 (0.33) | NPC1RAB9ALMNASMN1; SMN2PDE4A | |
| SCHEMBL30899554 | 0.76 | — | — | |
| SCHEMBL14083176 | 0.76 | — | — | |
| SCHEMBL30899565 | 0.76 | — | — | |
| SCHEMBL23280394 | 0.73 | CA1 (0.38) | LMNASMN1; SMN2MIF | |
| SCHEMBL30866952 | 0.72 | CA1 (0.62) | NPC1RAB9ALMNASMN1; SMN2MIF | |
| SCHEMBL21442739 | 0.67 | — | — | |
| SCHEMBL8148198 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008143729-A2 | MACROLIDE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | RIB-X PHARMACEUTICALS, INC. (US) | 2008-11-27 | — | — | WO | disclosed |