Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 13/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14024830 | 0.90 | CSF1R (0.48) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL2851744 | 0.88 | CSF1R (0.52) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL14024828 | 0.85 | CSF1R (0.52) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL14024835 | 0.85 | CSF1R (0.45) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL14396675 | 0.85 | CSF1R (0.53) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL2676785 | 0.85 | CSF1R (0.53) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL14024821 | 0.84 | CSF1R (0.61) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL14024819 | 0.84 | CSF1R (0.52) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL14024823 | 0.83 | CSF1R (0.47) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL14024842 | 0.82 | CSF1R (0.54) | CSF1RPDGFRBKITPDGFRAFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144062-A1 | CSF-1R INHIBITORS, COMPOSITIONS, AND METHODS OF USE | NOVARTIS AG (CH) | 2008-11-27 | — | — | WO | disclosed |