Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | TRAP1 | Q12931 | 5/20 | 0.39 |
| ▸ | HSP90B1 | P14625 | 3/20 | 0.39 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.39 |
| ▸ | USP1 | O94782 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | PNP | P00491 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12371690 | 0.78 | BIRC2 (0.42) | JAK2JAK3BIRC2TLR7USP1 | |
| SCHEMBL2270517 | 0.72 | JAK2 (0.47) | JAK2JAK3TLR7USP1ADORA3 | |
| SCHEMBL2269378 | 0.71 | BIRC2 (0.39) | JAK2JAK3BIRC2USP1 | |
| SCHEMBL2274336 | 0.71 | JAK2 (0.39) | JAK2JAK3USP1ALDH1A1 | |
| SCHEMBL2269368 | 0.71 | JAK2 (0.39) | JAK2JAK3USP1ALDH1A1 | |
| SCHEMBL2269372 | 0.71 | BIRC2 (0.39) | JAK2JAK3BIRC2USP1 | |
| SCHEMBL2274339 | 0.71 | BIRC2 (0.39) | JAK2JAK3BIRC2USP1 | |
| SCHEMBL13608332 | 0.71 | JAK2 (0.46) | JAK2JAK3TLR7USP1ADORA3 | |
| SCHEMBL13608364 | 0.69 | JAK2 (0.46) | JAK2JAK3TLR7USP1ADORA3 | |
| SCHEMBL12371651 | 0.67 | JAK2 (0.45) | JAK2JAK3TLR7USP1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008143674-A1 | PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2008-11-27 | — | — | WO | disclosed |