Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.56 |
| ▸ | KIT | P10721 | 5/20 | 0.54 |
| ▸ | CSF1R | P07333 | 4/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 4/20 | 0.47 |
| ▸ | LCK | P06239 | 3/20 | 0.47 |
| ▸ | ABL1 | P00519 | 3/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | HCK | P08631 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6726761 | 0.88 | BRAF (0.51) | BRAFKITCSF1RKDRRAF1 | |
| SCHEMBL3974567 | 0.83 | BRAF (0.53) | BRAFKITKDRPDGFRBMAPT | |
| SCHEMBL4754823 | 0.77 | CSF1R (0.65) | BRAFKITCSF1RKDRRAF1 | |
| SCHEMBL6455269 | 0.75 | BRAF (0.59) | BRAFKITCSF1RKDRRAF1 | |
| SCHEMBL6451067 | 0.75 | BRAF (0.59) | BRAFKITCSF1RKDRRAF1 | |
| SCHEMBL12786678 | 0.73 | BRAF (0.68) | BRAFKITCSF1RKDRRAF1 | |
| SCHEMBL26882822 | 0.73 | EGFR (0.44) | BRAFKITCSF1RRAF1 | |
| SCHEMBL6450311 | 0.72 | CSF1R (0.53) | BRAFKITCSF1RSRCABL1 | |
| SCHEMBL6450176 | 0.72 | CSF1R (0.53) | BRAFKITCSF1RKDRRAF1 | |
| SCHEMBL3806174 | 0.72 | BRAF (0.77) | BRAFKITCSF1RKDRRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |