SCHEMBL14028237

SCHEMBL14028237

N#Cc1c(N)nc(-c2ccccc2O)c(F)c1C1CCCNC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
IKBKB O14920 20/20 1.00
CHUK O15111 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL4946552 0.93 IKBKB (0.86) IKBKBCHUK
SCHEMBL14046386 0.86 IKBKB (0.76) IKBKBCHUK
SCHEMBL4946558 0.84 IKBKB (0.71) IKBKBCHUK
Hydrochloric Acid SCHEMBL5742086 0.78 IKBKB (0.76) IKBKBCHUK
SCHEMBL14028234 0.78 IKBKB (1.00) IKBKBCHUK
Hydrochloric Acid SCHEMBL4945830 0.78 IKBKB (0.98) IKBKBCHUK
Hydrochloric Acid SCHEMBL27601430 0.76 IKBKB (0.61) IKBKBCHUK
SCHEMBL7105018 0.72 IKBKB (0.88) IKBKBCHUK
SCHEMBL14491936 0.71 IKBKB (0.79) IKBKBCHUK
Hydrochloric Acid SCHEMBL5743268 0.71 IKBKB (0.63) IKBKBCHUK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7435743-B2 Pyridine derivatives BAYER AKTIENGESELLSCHAFT (DE) 2008-10-14 US disclosed
US-7232909-B2 Pyridine derivatives BAYER AKTIENGESELLSCHAFT (DE) 2007-06-19 US disclosed