Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.64 |
| ▸ | CTSD | P07339 | 15/20 | 0.57 |
| ▸ | BACE2 | Q9Y5Z0 | 13/20 | 0.57 |
| ▸ | REN | P00797 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8275996 | 0.96 | BACE1 (0.62) | BACE1CTSDBACE2REN | |
| SCHEMBL4065299 | 0.87 | BACE1 (0.85) | BACE1CTSDBACE2REN | |
| SCHEMBL4063882 | 0.84 | BACE1 (0.82) | BACE1CTSDBACE2REN | |
| SCHEMBL13953600 | 0.84 | BACE1 (0.79) | BACE1CTSDBACE2REN | |
| SCHEMBL13953601 | 0.84 | BACE1 (0.79) | BACE1CTSDBACE2REN | |
| SCHEMBL4066824 | 0.84 | BACE1 (0.79) | BACE1CTSDBACE2REN | |
| SCHEMBL5096595 | 0.81 | BACE1 (0.76) | BACE1CTSDBACE2REN | |
| SCHEMBL4069454 | 0.80 | BACE1 (0.81) | BACE1CTSDBACE2REN | |
| SCHEMBL5100312 | 0.80 | BACE1 (0.81) | BACE1CTSDBACE2REN | |
| SCHEMBL4010887 | 0.79 | BACE1 (0.69) | BACE1CTSDBACE2REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456186-B2 | Diphenylimidazopyrimidines as inhibitors of β-secretase | WYETH (US) | 2008-11-25 | — | — | US | disclosed |