Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 17/20 | 0.69 |
| ▸ | PLK3 | Q9H4B4 | 14/20 | 0.69 |
| ▸ | CDK2 | P24941 | 1/20 | 0.66 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.66 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.60 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | NEK2 | P51955 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4398141 | 0.96 | PLK1 (0.64) | PLK1PLK3CDK2IKBKEPIK3CD | |
| SCHEMBL14029656 | 0.96 | PLK1 (0.68) | PLK1PLK3CDK2IKBKEPIK3CD | |
| SCHEMBL14029663 | 0.93 | PLK1 (0.71) | PLK1PLK3CDK2IKBKEPIK3CD | |
| Trifluoroacetic Acid SCHEMBL4999376 | 0.92 | PLK1 (0.63) | PLK1PLK3CDK2IKBKEPIK3CD | |
| SCHEMBL4405873 | 0.91 | PLK1 (0.65) | PLK1PLK3CDK2IKBKEPIK3CD | |
| SCHEMBL14029661 | 0.90 | PLK1 (0.66) | PLK1PLK3CDK2IKBKEPIK3CD | |
| SCHEMBL4398145 | 0.89 | PLK1 (0.63) | PLK1PLK3CDK2IKBKEPIK3CD | |
| Trifluoroacetic Acid SCHEMBL4405442 | 0.89 | PLK1 (0.66) | PLK1PLK3CDK2IKBKEPIK3CD | |
| SCHEMBL4999172 | 0.87 | PLK1 (0.66) | PLK1PLK3CDK2IKBKEPIK3CD | |
| SCHEMBL4398403 | 0.87 | PLK1 (0.77) | PLK1PLK3CDK2IKBKEPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080249301-A1 | Regioselective Process for Preparing Benzimidazole Thiophenes | SMITHKLINE BEECHAM CORPORATION | 2008-10-09 | — | — | US | disclosed |
| US-20080249301-A1 | Regioselective Process for Preparing Benzimidazole Thiophenes | SMITHKLINE BEECHAM CORPORATION | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249301-A1 | Regioselective Process for Preparing Benzimidazole Thiophenes | CYP3A4, CYP2C19, CYP2B6 | PLK1 1718/4885PLK3 2097/4885CDK2 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.