Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.41 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | STK10 | O94804 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | HCK | P08631 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1227728 | 0.81 | KDR (0.53) | KDRMRGPRX1MAP2K1CYP3A4FGFR1 | |
| SCHEMBL1226469 | 0.78 | KDR (0.61) | KDRCYP3A4FGFR1KCNH2MET | |
| SCHEMBL4106716 | 0.78 | MAP2K1 (0.41) | KDRMRGPRX1MAP2K1CYP3A4KCNH2 | |
| SCHEMBL1227475 | 0.77 | KDR (0.63) | KDRMAP2K1CYP3A4MET | |
| SCHEMBL1227851 | 0.76 | KDR (0.63) | KDRCYP3A4KCNH2METMEN1 | |
| SCHEMBL4045888 | 0.75 | KDR (0.65) | KDRMAP2K1EGFR | |
| SCHEMBL1683387 | 0.73 | SCN9A (0.43) | KDRMAP2K1CYP3A4MET | |
| SCHEMBL4051489 | 0.71 | KDR (0.46) | KDRMAP2K1EGFRMET | |
| SCHEMBL14579509 | 0.70 | KDR (0.42) | KDRMAP2K1EGFR | |
| SCHEMBL1683427 | 0.68 | KDR (0.70) | KDRCYP3A4FGFR1KCNH2EPHB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432373-B2 | Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2008-10-07 | — | — | US | disclosed |