Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 3/20 | 0.61 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.45 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ACP3 | P15309 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9614053 | 0.87 | PDE2A (0.49) | PDE2AADORA2AADORA1PTPN5TOP2A | |
| SCHEMBL14622353 | 0.84 | PDE2A (0.62) | PDE2ATOP2ATOP2BCYP1A2CYP2D6 | |
| SCHEMBL14033355 | 0.82 | PDE2A (0.54) | PDE2AIDO1TDO2MAPTATM | |
| SCHEMBL6564729 | 0.80 | TOP2A (0.48) | PDE2AADORA2AADORA1PTPN5TOP2A | |
| SCHEMBL477421 | 0.78 | IDO1 (0.56) | TOP2ATOP2BCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL18075371 | 0.76 | PDE2A (1.00) | PDE2ACYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4633442 | 0.75 | PDE2A (0.63) | PDE2ACYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4633445 | 0.75 | PDE2A (0.63) | PDE2ACYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL477425 | 0.75 | ACP3 (0.59) | ADORA2AADORA1TOP2ATOP2BACP3 | |
| SCHEMBL477694 | 0.75 | ACP3 (0.59) | ADORA2AADORA1TOP2ATOP2BACP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |