Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.66 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.66 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.66 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.66 |
| ▸ | GCGR | P47871 | 2/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5097818 | 0.93 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5104332 | 0.88 | MAPK14 (0.66) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5097762 | 0.88 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5104620 | 0.86 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5097718 | 0.84 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL5104338 | 0.83 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5139713 | 0.82 | MAPK14 (0.84) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5104603 | 0.82 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5104636 | 0.81 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL5104532 | 0.81 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442713-B2 | 2-thio-substituted imidazole derivatives and their use in pharmaceutics | MERCKLE GMBH (DE) | 2008-10-28 | — | — | US | disclosed |
| US-7442713-B2 | 2-thio-substituted imidazole derivatives and their use in pharmaceutics | MERCKLE GMBH (DE) | 2008-10-28 | — | — | US | disclosed |