Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.80 |
| ▸ | HDAC8 | Q9BY41 | 18/20 | 0.76 |
| ▸ | HDAC2 | Q92769 | 16/20 | 0.76 |
| ▸ | HDAC6 | Q9UBN7 | 16/20 | 0.76 |
| ▸ | HDAC3 | O15379 | 15/20 | 0.76 |
| ▸ | HDAC4 | P56524 | 15/20 | 0.76 |
| ▸ | HDAC7 | Q8WUI4 | 15/20 | 0.76 |
| ▸ | HDAC10 | Q969S8 | 15/20 | 0.76 |
| ▸ | HDAC11 | Q96DB2 | 15/20 | 0.76 |
| ▸ | HDAC9 | Q9UKV0 | 15/20 | 0.76 |
| ▸ | HDAC5 | Q9UQL6 | 15/20 | 0.76 |
| ▸ | BRD4 | O60885 | 1/20 | 0.76 |
| ▸ | ESR1 | P03372 | 1/20 | 0.76 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.76 |
| ▸ | PDE4A | P27815 | 1/20 | 0.76 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.76 |
| ▸ | HTR6 | P50406 | 1/20 | 0.76 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.76 |
| ▸ | ASPH | Q12797 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1403531 | 1.00 | HDAC1 (0.80) | HDAC1HDAC8HDAC2HDAC6HDAC3 | |
| SCHEMBL1403546 | 0.89 | HDAC1 (0.91) | HDAC1HDAC8HDAC2HDAC6HDAC3 | |
| SCHEMBL1403548 | 0.89 | HDAC1 (0.91) | HDAC1HDAC8HDAC2HDAC6HDAC3 | |
| SCHEMBL5047233 | 0.89 | HDAC1 (1.00) | HDAC1HDAC8HDAC2HDAC6HDAC3 | |
| SCHEMBL1403172 | 0.88 | AKR1C3 (0.64) | HDAC1HDAC8HDAC2HDAC6HDAC3 | |
| SCHEMBL1403175 | 0.88 | AKR1C3 (0.64) | HDAC1HDAC8HDAC2HDAC6HDAC3 | |
| SCHEMBL1403019 | 0.87 | HDAC1 (0.61) | HDAC1HDAC8HDAC2HDAC6HDAC3 | |
| SCHEMBL1403017 | 0.87 | HDAC1 (0.61) | HDAC1HDAC8HDAC2HDAC6HDAC3 | |
| Belinostat SCHEMBL375906 | 0.87 | HDAC1 (1.00) | HDAC1HDAC8HDAC2HDAC6HDAC3 | |
| Belinostat SCHEMBL29379950 | 0.87 | HDAC1 (1.00) | HDAC1HDAC8HDAC2HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292593-A2 | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors | TopoTarget UK Limited (GB) | 2011-03-09 | — | — | EP | disclosed |
| US-7557140-B2 | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors | TOPOTARGET UK LIMITED (GB) | 2009-07-07 | — | — | US | disclosed |
| US-7407988-B2 | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors | TOPOTARGET UK LIMITED (GB) | 2008-08-05 | — | — | US | disclosed |
| US-20080161401-A1 | CARBAMIC ACID COMPOUNDS COMPRISING A SULFONAMIDE LINKAGE AS HDAC INHIBITORS | TOPOTARGET UK LIMITED (GB) | 2008-07-03 | — | — | US | disclosed |
| US-7183298-B2 | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors | TOPOTARGET UK LIMITED (GB) | 2007-02-27 | — | — | US | disclosed |
| US-20070004806-A1 | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors | TOPOTARGET UK LIMITED (GB) | 2007-01-04 | — | — | US | disclosed |
| US-20050107445-A1 | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors | PROLIFIX LIMITED (GB) | 2005-05-19 | — | — | US | disclosed |
| US-6888027-B2 | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors | TOPOTARGET UK LIMITED (GB) | 2005-05-03 | — | — | US | disclosed |
| US-20050085515-A1 | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors | TOPO TARGET UK LIMITED, (GB) | 2005-04-21 | — | — | US | disclosed |
| US-20040077726-A1 | Carbamic acid compounds comprising a sulfonamide linkage as hdac inhibitors | SWK FUNDING LLC | 2004-04-22 | — | — | US | disclosed |
| EP-1328510-A2 | CARBAMIC ACID COMPOUNDS COMPRISING A SULFONAMIDE LINKAGE AS HDAC INHIBITORS | PROLIFIX LTD. (GB) | 2003-07-23 | — | — | EP | disclosed |
| WO-2002030879-A2 | CARBAMIC ACID COMPOUNDS COMPRISING A SULFONAMIDE LINKAGE AS HDAC INHIBITORS | PROLIFIX LIMITED (GB) | 2002-04-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107445-A1 | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors | HDAC1, HDAC11, HDAC3 | HDAC1 1/4885HDAC8 4/4885HDAC2 5/4885 |
| US-20070004806-A1 | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors | HDAC1, HDAC11, HDAC3 | HDAC1 1/4885HDAC8 4/4885HDAC2 5/4885 |
| US-20080161401-A1 | CARBAMIC ACID COMPOUNDS COMPRISING A SULFONAMIDE LINKAGE AS HDAC INHIBITORS | HDAC1, HDAC11, HDAC3 | HDAC1 1/4885HDAC8 4/4885HDAC2 5/4885 |
| US-20040077726-A1 | Carbamic acid compounds comprising a sulfonamide linkage as hdac inhibitors | HDAC1, HDAC11, HDAC2 | HDAC1 1/4885HDAC8 4/4885HDAC2 3/4885 |
| US-20050085515-A1 | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors | HDAC1, HDAC11, HDAC3 | HDAC1 1/4885HDAC8 4/4885HDAC2 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.