SCHEMBL14035484

SCHEMBL14035484

C[C@@H](c1cc(F)cc(F)c1F)N1CCN(C(=O)OC(C)(C)C)CC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.46
CYP3A5 P20815 2/20 0.46
DPP4 P27487 1/20 0.42
GPR119 Q8TDV5 6/20 0.41
HTT P42858 2/20 0.40
ATM Q13315 1/20 0.40
NPC1 O15118 1/20 0.40
ALDH1A1 P00352 1/20 0.40
MAPT P10636 1/20 0.40
MAPK1 P28482 1/20 0.40
RAB9A P51151 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.38
F13A1 P00488 1/20 0.38
TGM2 P21980 1/20 0.38
TGM1 P22735 1/20 0.38
USP2 O75604 1/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
TBK1 Q9UHD2 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9963092 0.80 CYP3A4 (0.48) CYP3A4CYP3A5GPR119HTTATM
SCHEMBL660699 0.77 HTT (0.51) CYP3A4CYP3A5GPR119HTTATM
SCHEMBL3837657 0.77 HTT (0.51) CYP3A4CYP3A5GPR119HTTATM
SCHEMBL3837654 0.77 HTT (0.51) CYP3A4CYP3A5GPR119HTTATM
SCHEMBL18249594 0.76 DPP4 (0.42) CYP3A4CYP3A5DPP4GPR119SMN1; SMN2
SCHEMBL18249625 0.76 DPP4 (0.42) DPP4GPR119MAPTSMN1; SMN2
SCHEMBL28483062 0.74 CYP3A4 (0.52) CYP3A4CYP3A5DPP4GPR119MAPT
SCHEMBL1865523 0.73 SMN1; SMN2 (0.40) CYP3A4CYP3A5DPP4GPR119ALDH1A1
SCHEMBL1865525 0.73 SMN1; SMN2 (0.40) CYP3A4CYP3A5DPP4GPR119ALDH1A1
SCHEMBL31647258 0.73 CYP3A4 (0.56) CYP3A4CYP3A5DPP4HTTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008134036-A1 ALPHA-SUBSTITUTED ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-α]PYRIMIDINE AMIDE DERIVATIVES PANACOS PHARMACEUTICALS, INC. (US) 2008-11-06 WO disclosed