Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.65 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31504074 | 0.79 | NOTUM (1.00) | NOTUMDRD2DRD4HTTPTK2B | |
| SCHEMBL31504075 | 0.79 | NOTUM (1.00) | NOTUMDRD2DRD4HTTPTK2B | |
| SCHEMBL8526899 | 0.79 | NOTUM (1.00) | NOTUMDRD2DRD4HTTPTK2B | |
| SCHEMBL31038041 | 0.72 | NOTUM (0.66) | NOTUMDRD2DRD4HTTPTK2B | |
| SCHEMBL8526283 | 0.72 | NOTUM (0.66) | NOTUMDRD2DRD4HTR2AHTR2C | |
| SCHEMBL8530600 | 0.71 | NOTUM (0.59) | NOTUMDRD2DRD4HTR2AHTR2C | |
| SCHEMBL24651170 | 0.68 | NOTUM (0.66) | NOTUMDRD2DRD4HTTPTK2B | |
| SCHEMBL1575886 | 0.68 | NOTUM (0.66) | NOTUMDRD2DRD4HTTPTK2B | |
| SCHEMBL31170822 | 0.68 | NOTUM (0.78) | NOTUMDRD2DRD4HTTHTR2A | |
| SCHEMBL10854921 | 0.68 | NOTUM (0.78) | NOTUMDRD2DRD4HTTHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449575-B2 | Substituted diamino-1,3,5-triazine derivatives | JANSSEN PHARMACEUTICA, INC. (BE) | 2008-11-11 | — | — | US | disclosed |