Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 16/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 11/20 | 0.48 |
| ▸ | USP2 | O75604 | 4/20 | 0.48 |
| ▸ | CASP1 | P29466 | 8/20 | 0.44 |
| ▸ | CASP7 | P55210 | 8/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10084717 | 0.91 | EGLN1 (0.45) | KMT2ACYP1A2ALDH1A1HSD17B10USP2 | |
| SCHEMBL10084946 | 0.90 | EGLN1 (0.44) | KMT2ACYP1A2ALDH1A1HSD17B10USP2 | |
| SCHEMBL337429 | 0.88 | EGLN1 (0.56) | KMT2ACYP1A2ALDH1A1HSD17B10USP2 | |
| SCHEMBL14035346 | 0.82 | KMT2A (0.60) | KMT2ACYP1A2ALDH1A1HSD17B10USP2 | |
| SCHEMBL10084865 | 0.82 | PTPN11 (0.46) | KMT2ACYP1A2ALDH1A1USP2CYP2C19 | |
| SCHEMBL10084714 | 0.79 | EGLN1 (0.41) | KMT2AALDH1A1HSD17B10EGLN1MEN1 | |
| SCHEMBL336625 | 0.79 | EGLN1 (0.59) | CASP1EGLN1HIF1A | |
| SCHEMBL10085261 | 0.79 | EGLN1 (0.46) | KMT2ACYP1A2ALDH1A1HSD17B10USP2 | |
| SCHEMBL10085743 | 0.79 | EGLN1 (0.46) | KMT2AALDH1A1USP2EGLN1TSHR | |
| SCHEMBL336409 | 0.78 | EGLN1 (0.58) | CASP1EGLN1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008137084-A2 | DIAZAQUINOLONES THAT INHIBIT PROLYL HYDROXYLASE ACTIVITY | AMGEN INC. (US) | 2008-11-13 | — | — | WO | disclosed |