Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RORC | P51449 | 3/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1465894 | 0.90 | AKR1C3 (0.54) | AKR1C3AKR1C1LMNASMN1; SMN2KMT2A | |
| SCHEMBL1466281 | 0.89 | AKR1C3 (0.64) | AKR1C3AKR1C1LMNASMN1; SMN2KMT2A | |
| SCHEMBL12748753 | 0.85 | AKR1C3 (0.48) | AKR1C3AKR1C1LMNASMN1; SMN2KMT2A | |
| SCHEMBL1466938 | 0.75 | AKR1C3 (0.56) | AKR1C3AKR1C1LMNASMN1; SMN2KMT2A | |
| SCHEMBL1468084 | 0.74 | AKR1C3 (0.54) | AKR1C3AKR1C1LMNASMN1; SMN2KMT2A | |
| SCHEMBL12748677 | 0.74 | AKR1C3 (0.54) | AKR1C3AKR1C1LMNASMN1; SMN2KMT2A | |
| SCHEMBL12748738 | 0.73 | AKR1C3 (0.64) | AKR1C3AKR1C1LMNASMN1; SMN2KMT2A | |
| SCHEMBL12748680 | 0.73 | AKR1C3 (0.64) | AKR1C3AKR1C1LMNASMN1; SMN2KMT2A | |
| SCHEMBL12748754 | 0.73 | AKR1C3 (0.43) | AKR1C3AKR1C1RORCPPARGPPARD | |
| SCHEMBL12748662 | 0.73 | AKR1C3 (0.53) | AKR1C3AKR1C1LMNASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1990335-A1 | 17 BETA HSD TYPE 5 INHIBITOR | Astellas Pharma Inc. (JP) | 2008-11-12 | — | — | EP | disclosed |