Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.32 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL33808 | 0.68 | — | — | |
| SCHEMBL6011711 | 0.68 | PDE10A (0.62) | PDE10ATSHRCASP1HSD17B1HSD17B2 | |
| Hydrochloric Acid SCHEMBL27589678 | 0.66 | PDE10A (0.95) | PDE10ATSHRCASP1ESR2ESR1 | |
| Hydrochloric Acid SCHEMBL6518172 | 0.66 | PDE10A (0.95) | PDE10ATSHRCASP1ESR2ESR1 | |
| Bromide SCHEMBL4051270 | 0.66 | PDE10A (0.95) | PDE10ATSHRCASP1ESR2ESR1 | |
| SCHEMBL3331554 | 0.66 | PDE10A (0.50) | PDE10ATSHRCASP1HSD17B1HSD17B2 | |
| Bromide SCHEMBL6648299 | 0.65 | PDE10A (0.91) | PDE10ATSHRCASP1ESR2ESR1 | |
| Dimethylamine SCHEMBL9109642 | 0.63 | PDE10A (0.86) | PDE10ATSHRCASP1ESR2ESR1 | |
| Trimethylammonium SCHEMBL27731909 | 0.63 | PDE10A (0.86) | PDE10ATSHRCASP1ESR2ESR1 | |
| SCHEMBL6573729 | 0.63 | PDE10A (0.59) | PDE10ATSHRCASP1HSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008133955-A1 | 6-PHENYLPYRIMIDINONES AS PIM MODULATORS | EXELIXIS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |