Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.49 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | GNRHR | P30968 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014023 | 0.80 | BCHE (0.45) | ALDH1A1BCHEMAPK1SIGMAR1ACHE | |
| SCHEMBL8238364 | 0.78 | BCHE (0.70) | ALDH1A1CARM1PRMT6BCHECYP2D6 | |
| SCHEMBL10684393 | 0.78 | BCHE (0.70) | ALDH1A1CARM1PRMT6BCHECYP2D6 | |
| Hydrochloric Acid SCHEMBL7376929 | 0.76 | ATM (0.64) | ALDH1A1BCHESIGMAR1CYP2D6CYP1A2 | |
| SCHEMBL15121139 | 0.75 | SLC6A4 (0.39) | MAPK1HTR1ASLC6A4 | |
| SCHEMBL12658795 | 0.74 | BCHE (0.64) | ALDH1A1CARM1PRMT6BCHECYP2D6 | |
| SCHEMBL21393195 | 0.74 | CYP2D6 (0.62) | ALDH1A1POLBCARM1PRMT6BCHE | |
| SCHEMBL12424602 | 0.74 | CYP2D6 (0.62) | ALDH1A1POLBCARM1PRMT6BCHE | |
| SCHEMBL13182778 | 0.74 | CYP2D6 (0.62) | ALDH1A1POLBCARM1PRMT6BCHE | |
| SCHEMBL21929519 | 0.74 | SLC6A4 (0.39) | HTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449475-B2 | Tricyclic spiropiperidines or spiropyrrolidines | ASTRAZENECA AB (SE) | 2008-11-11 | — | — | US | disclosed |