Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 18/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13322819 | 0.91 | CHEK1 (0.49) | CHEK1PIM1PIM3PRKCAGSK3B | |
| SCHEMBL13322817 | 0.83 | CHEK1 (0.52) | CHEK1PIM1PIM3PRKCAGSK3B | |
| SCHEMBL13322823 | 0.82 | CHEK1 (0.66) | CHEK1PIM1PIM3PRKCAGSK3B | |
| SCHEMBL13322872 | 0.81 | CHEK1 (0.56) | CHEK1PIM1PIM3 | |
| SCHEMBL13322797 | 0.81 | CHEK1 (0.56) | CHEK1PIM1PIM3PRKCAGSK3B | |
| SCHEMBL14207423 | 0.81 | PIM1 (0.56) | CHEK1PIM1PIM3PRKCAGSK3B | |
| SCHEMBL13322786 | 0.81 | CHEK1 (0.57) | CHEK1PIM1PIM3PRKCAGSK3B | |
| SCHEMBL13322895 | 0.78 | CHEK1 (0.50) | CHEK1PIM1PIM3 | |
| SCHEMBL13322818 | 0.78 | CHEK1 (0.65) | CHEK1PIM1PIM3 | |
| SCHEMBL14038995 | 0.78 | CHEK1 (0.54) | CHEK1PIM1PIM3PRKCAGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318735-B2 | 2-aminothiazole-4-carboxylic amides as protein kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-11-27 | — | — | US | disclosed |
| US-8318735-B2 | 2-aminothiazole-4-carboxylic amides as protein kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-11-27 | — | — | US | disclosed |