Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 19/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13322987 | 0.91 | CHEK1 (0.54) | CHEK1PIM1PIM3 | |
| SCHEMBL13322995 | 0.88 | CHEK1 (0.55) | CHEK1PIM1PIM3 | |
| SCHEMBL14039007 | 0.88 | CHEK1 (0.56) | CHEK1PIM1PIM3 | |
| SCHEMBL14038984 | 0.84 | CHEK1 (0.55) | CHEK1PIM1PIM3 | |
| SCHEMBL13322979 | 0.84 | CHEK1 (0.56) | CHEK1PIM1PIM3 | |
| SCHEMBL13322975 | 0.83 | CHEK1 (0.56) | CHEK1PIM1PIM3 | |
| SCHEMBL13323002 | 0.83 | CHEK1 (0.57) | CHEK1PIM1PIM3 | |
| SCHEMBL13322989 | 0.83 | CHEK1 (0.53) | CHEK1 | |
| SCHEMBL13322984 | 0.83 | CHEK1 (0.55) | CHEK1PIM1PIM3 | |
| SCHEMBL14039008 | 0.82 | CHEK1 (0.51) | CHEK1PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318735-B2 | 2-aminothiazole-4-carboxylic amides as protein kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-11-27 | — | — | US | disclosed |
| US-8318735-B2 | 2-aminothiazole-4-carboxylic amides as protein kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-11-27 | — | — | US | disclosed |