Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 20/20 | 0.50 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.50 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.50 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.50 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.50 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.50 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.50 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.50 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.50 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.50 |
| ▸ | GIPR | P48546 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2667122 | 0.97 | GCGR (0.53) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL14039403 | 0.93 | GCGR (0.51) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL14039411 | 0.90 | GCGR (0.52) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL2666922 | 0.86 | GCGR (0.55) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL14039372 | 0.83 | GCGR (0.52) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL14039369 | 0.80 | GCGR (0.58) | GCGR | |
| SCHEMBL14039408 | 0.80 | GCGR (0.53) | GCGR | |
| SCHEMBL14039360 | 0.78 | GCGR (0.55) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL14039358 | 0.78 | GCGR (0.53) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL14039371 | 0.78 | GCGR (0.54) | GCGRADCY6ADCY3ADCY9ADCY5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318760-B2 | Type 2 diabetes, atherosclerosis; compounds are N-(2-carboxyethyl)benzamides or N-tetrazolyl derivatives of benzamides; glucagon antagonists | MERCK SHARP & DOHME CORP. (US) | 2012-11-27 | — | — | US | disclosed |