Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 15/20 | 0.61 |
| ▸ | KDR | P35968 | 15/20 | 0.61 |
| ▸ | KIT | P10721 | 11/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | DHPS | P49366 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 3/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL138544 | 0.92 | PDGFRB (0.64) | PDGFRBKDRKITFGFR1AURKA | |
| SCHEMBL153706 | 0.92 | PDGFRB (0.64) | PDGFRBKDRKITFGFR1AURKA | |
| SCHEMBL154610 | 0.91 | PDGFRB (0.63) | PDGFRBKDRKITFGFR1FLT3 | |
| SCHEMBL138509 | 0.91 | PDGFRB (0.63) | PDGFRBKDRKITFGFR1FLT3 | |
| SCHEMBL3133179 | 0.87 | PDGFRB (0.58) | PDGFRBKDRKITFGFR1AURKA | |
| SCHEMBL3133175 | 0.87 | PDGFRB (0.58) | PDGFRBKDRKITFGFR1AURKA | |
| SCHEMBL154661 | 0.86 | PDGFRB (0.72) | PDGFRBKDRKITFGFR1FLT3 | |
| SCHEMBL139982 | 0.86 | PDGFRB (0.72) | PDGFRBKDRKITFGFR1FLT3 | |
| SCHEMBL140057 | 0.85 | PDGFRB (0.65) | PDGFRBKDRKITFGFR1RET | |
| SCHEMBL154916 | 0.85 | PDGFRB (0.65) | PDGFRBKDRKITFGFR1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058107-A1 | PYRROLO [3,2-C] PYRIDINE-4-ONE 2-INDOLINONE PROTEIN KINASE INHIBITORS | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2012-03-08 | — | — | US | disclosed |
| US-20120058107-A1 | PYRROLO [3,2-C] PYRIDINE-4-ONE 2-INDOLINONE PROTEIN KINASE INHIBITORS | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058107-A1 | PYRROLO [3,2-C] PYRIDINE-4-ONE 2-INDOLINONE PROTEIN KINASE INHIBITORS | DMPK, PDPK1, PRKAR2A | PDGFRB 657/4885KDR 1027/4885KIT 456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.