Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 10/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.42 |
| ▸ | SPR | P35270 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4765914 | 0.89 | MAPK14 (0.46) | MAPK1MAPK3HDAC3HDAC1HDAC2 | |
| SCHEMBL4775106 | 0.89 | MAPK14 (0.48) | MAPK1MAPK3HDAC3HDAC1HDAC2 | |
| SCHEMBL14004218 | 0.87 | HDAC3 (0.46) | MAPK1MAPK3HDAC3HDAC1HDAC2 | |
| SCHEMBL14004217 | 0.76 | MAPK8 (0.48) | MAPK3MAPK8MAPK9MAPK10 | |
| SCHEMBL14004188 | 0.72 | MAPK1 (0.49) | MAPK1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL4771405 | 0.72 | MAPK14 (0.43) | MAPK1MAPK3HDAC3HDAC1HDAC2 | |
| SCHEMBL1517480 | 0.71 | HDAC3 (0.45) | MAPK1MAPK3HDAC3HDAC1HDAC2 | |
| SCHEMBL4765878 | 0.69 | MAPK14 (0.59) | MAPK1MAPK14LCKMAPK8MAPK9 | |
| SCHEMBL4776143 | 0.69 | MAPK14 (0.44) | MAPK1MAPK14LCKMAPK8MAPK9 | |
| SCHEMBL4776152 | 0.68 | MAPK14 (0.53) | MAPK1MAPK14MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485390-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE P38 KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-10-08 | — | — | EP | disclosed |