Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 12/20 | 0.57 |
| ▸ | JAK1 | P23458 | 11/20 | 0.57 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 4/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.45 |
| ▸ | PIK3C2G | O75747 | 2/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 2/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1474449 | 0.96 | BRD4 (0.59) | JAK3JAK1BRD4SYKPIK3CD | |
| SCHEMBL1476506 | 0.94 | JAK3 (0.53) | JAK3JAK1BRD4SYKPIK3CD | |
| SCHEMBL12638706 | 0.90 | JAK3 (0.48) | JAK3JAK1BRD4SYKPIK3CD | |
| SCHEMBL1474404 | 0.90 | JAK3 (0.72) | JAK3JAK1BRD4SYKPIK3CD | |
| SCHEMBL1475146 | 0.88 | BRD4 (0.52) | JAK3JAK1BRD4SYKPIK3CD | |
| SCHEMBL17669875 | 0.87 | JAK1 (0.59) | JAK3JAK1SYKPIK3CDPIK3C2G | |
| SCHEMBL1475319 | 0.85 | JAK3 (0.47) | JAK3JAK1SYKPIK3CDPIK3C2G | |
| SCHEMBL12638686 | 0.83 | JAK3 (0.47) | JAK3JAK1BRD4SYKPIK3CD | |
| SCHEMBL1475290 | 0.82 | JAK3 (0.62) | JAK3JAK1SYKPIK3CDPIK3C2G | |
| SCHEMBL1474895 | 0.81 | STK4 (0.50) | JAK3JAK1SYKPIK3CDPIK3C2G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008118822-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2008-10-02 | — | — | WO | disclosed |