Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 5/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | BRAF | P15056 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14042474 | 0.98 | LCK (0.58) | LCKMAPK14KITSRCCSF1R | |
| SCHEMBL14042254 | 0.95 | LCK (0.56) | LCKMAPK14KITSRCCSF1R | |
| SCHEMBL4863711 | 0.92 | LCK (0.57) | LCKMAPK14KITSRCCSF1R | |
| SCHEMBL14042664 | 0.90 | LCK (0.51) | LCKMAPK14KITSRCCSF1R | |
| SCHEMBL14042656 | 0.89 | LCK (0.53) | LCKMAPK14KITSRCCSF1R | |
| SCHEMBL4746517 | 0.87 | LCK (0.63) | LCKMAPK14KITSRCCSF1R | |
| SCHEMBL14042708 | 0.87 | BRAF (0.61) | LCKMAPK14KITSRCCSF1R | |
| SCHEMBL14042471 | 0.86 | LCK (0.65) | LCKMAPK14KITSRCCSF1R | |
| SCHEMBL14042261 | 0.86 | LCK (0.57) | LCKMAPK14KITSRCCSF1R | |
| SCHEMBL14042720 | 0.86 | LCK (0.55) | LCKMAPK14KITSRCCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124393-A1 | BENZOTHIAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-10-16 | — | — | WO | disclosed |