Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.67 |
| ▸ | CDK2 | P24941 | 9/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | CCR6 | P51684 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14562350 | 0.91 | GSK3B (0.63) | GSK3BCDK2KDM4EMAPTMAPK1 | |
| SCHEMBL13122691 | 0.90 | GSK3B (0.64) | GSK3BCDK2KDM4EMAPTMAPK1 | |
| SCHEMBL13117972 | 0.90 | GSK3B (0.61) | GSK3BCDK2KDM4EMAPTMAPK1 | |
| SCHEMBL13122438 | 0.89 | GSK3B (0.60) | GSK3BCDK2KDM4EMAPTMAPK1 | |
| SCHEMBL12954499 | 0.89 | GSK3B (0.60) | GSK3BCDK2KDM4EMAPTMAPK1 | |
| SCHEMBL14562351 | 0.89 | CDK2 (0.61) | GSK3BCDK2KDM4EMAPTMAPK1 | |
| SCHEMBL12954262 | 0.89 | CDK2 (0.68) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL14572802 | 0.89 | GSK3B (0.71) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL13121302 | 0.88 | GSK3B (0.59) | GSK3BCDK2KDM4EMAPTMAPK1 | |
| SCHEMBL13122410 | 0.88 | GSK3B (0.62) | GSK3BCDK2KDM4EMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130570-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |
| US-7196078-B2 | Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPOARTION (US) | 2007-03-27 | — | — | US | disclosed |