Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 13/20 | 0.48 |
| ▸ | CDK7 | P50613 | 4/20 | 0.46 |
| ▸ | CDK2 | P24941 | 7/20 | 0.46 |
| ▸ | CDK9 | P50750 | 5/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.46 |
| ▸ | CDK1 | P06493 | 4/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.45 |
| ▸ | CCNH | P51946 | 2/20 | 0.45 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.44 |
| ▸ | GSK3A | P49840 | 2/20 | 0.42 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CCNK | O75909 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15579645 | 0.92 | GSK3B (0.47) | GSK3BCDK7CDK2CDK9CDK5 | |
| SCHEMBL15579646 | 0.92 | GSK3B (0.47) | GSK3BCDK7CDK2CDK9CDK5 | |
| SCHEMBL12953874 | 0.91 | CDK2 (0.55) | GSK3BCDK7CDK2CDK9CDK5 | |
| SCHEMBL11930872 | 0.91 | CDK2 (0.55) | GSK3BCDK7CDK2CDK9CDK5 | |
| SCHEMBL12952993 | 0.90 | GSK3B (0.45) | GSK3BCDK7CDK2CDK9CDK5 | |
| SCHEMBL12953007 | 0.90 | GSK3B (0.45) | GSK3BCDK7CDK2CDK9CDK5 | |
| SCHEMBL12953465 | 0.89 | CDK2 (0.55) | GSK3BCDK7CDK2CDK9CDK5 | |
| SCHEMBL14276459 | 0.89 | CDK2 (0.55) | GSK3BCDK7CDK2CDK9CDK5 | |
| SCHEMBL12953480 | 0.89 | GSK3B (0.45) | GSK3BCDK7CDK2CDK9CDK5 | |
| SCHEMBL12953642 | 0.89 | GSK3B (0.45) | GSK3BCDK7CDK2CDK9CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130570-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |
| WO-2008130569-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |