Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.57 |
| ▸ | CDK2 | P24941 | 9/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13304958 | 0.90 | GSK3B (0.54) | GSK3BCDK2CCNA2CCNA1ADORA2A | |
| SCHEMBL14043202 | 0.89 | GSK3B (0.72) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL14050781 | 0.88 | GSK3B (0.57) | GSK3BCDK2CCNA2CCNA1ADORA2A | |
| SCHEMBL12954304 | 0.86 | GSK3B (0.55) | GSK3BCDK2CCNA2CCNA1ADORA2A | |
| SCHEMBL14043294 | 0.85 | GSK3B (0.49) | GSK3BCDK2CCNA2CCNA1ADORA2A | |
| SCHEMBL13304787 | 0.83 | GSK3B (0.47) | GSK3BCDK2CCNA2CCNA1ADORA2A | |
| SCHEMBL14050928 | 0.81 | GSK3B (0.61) | GSK3BCDK2CCNA2CCNA1MEN1 | |
| SCHEMBL13305327 | 0.81 | GSK3B (0.45) | GSK3BCDK2CCNA2CCNA1MEN1 | |
| SCHEMBL13305701 | 0.81 | GSK3B (0.45) | GSK3BCDK2CCNA2CCNA1ADORA2A | |
| SCHEMBL14043290 | 0.80 | GSK3B (0.60) | GSK3BCDK2CCNA2CCNA1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130570-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |
| WO-2008130569-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |