Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.66 |
| ▸ | AURKA | O14965 | 8/20 | 0.61 |
| ▸ | LCK | P06239 | 8/20 | 0.61 |
| ▸ | TEK | Q02763 | 8/20 | 0.61 |
| ▸ | MET | P08581 | 7/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | LYN | P07948 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | FLT1 | P17948 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2746928 | 0.91 | KDR (0.69) | KDRAURKALCKTEKMET | |
| SCHEMBL2747611 | 0.91 | KDR (0.72) | KDRAURKALCKTEKMET | |
| SCHEMBL2746336 | 0.90 | KDR (0.72) | KDRAURKALCKTEKMET | |
| SCHEMBL2747364 | 0.89 | KDR (0.72) | KDRAURKALCKTEKMET | |
| SCHEMBL4556673 | 0.89 | KDR (0.66) | KDRAURKALCKTEKMET | |
| SCHEMBL2747380 | 0.89 | KDR (0.75) | KDRAURKALCKTEKMET | |
| SCHEMBL2746837 | 0.89 | KDR (0.66) | KDRAURKALCKTEKMET | |
| SCHEMBL2747703 | 0.89 | KDR (0.72) | KDRAURKALCKTEKMET | |
| SCHEMBL4549024 | 0.89 | KDR (0.68) | KDRAURKALCKTEKMET | |
| SCHEMBL4549015 | 0.89 | KDR (0.71) | KDRAURKALCKTEKMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435823-B2 | Compounds and methods of use | AMGEN INC. (US) | 2008-10-14 | — | — | US | disclosed |